MICRO CRYSTALLINE CELLULOSE (PHARMA, FOOD & NON PHARMA GRADE)
[EIRI/EDPR/3366] J.C.: 1450
INTRODUCTION
Microcrystalline cellulose, also known as MCC or cellulose gel, is commonly used as a binder and disintegrant in pharmaceutical tablets, as a suspending agent in liquid pharmaceutical formulations, and as a binder and stabilizer in food applications including beverages and as stabilizers, binders, disintegrants and processing aids in industrial applications, household products such as detergent and/or bleach tablets, agricultural formulations, and personal care products such as dentifrices and cosmetics. In foods, MCC is used alone or in coprocessed modifications as a fat replacer. The classic process for MCC production is acid hydrolysis of purified cellulose. In efforts to reduce the cost while maintaining or improving the quality of MCC, various alternative processes have been proposed. Among these are steam explosion, reactive extrusion, one-step hydrolysis and bleaching, and partial hydrolysis of a semi-crystalline cellulose and water reaction liquor in a reactor pressurized with oxygen and/or carbon dioxide gas and operating at 100 to 200°C. In the steam explosion process of Ha et al, a cellulose source material, such as wood chips, is contacted in a pressure reactor vessel with pressurized steam at a temperature of at least about 170°C for a brief period, concluding with a rapid release of the steam pressure (the "steam explosion" effect).
COST ESTIMATION
Plant Capacity 5 MT/Day
Land & Building (2000 sq.mt.) Rs. 2.97 Cr
Plant & Machinery Rs. 4.00 Cr
Working Capital for 2 Months Rs. 2.03 Cr
Total Capital Investment Rs. 9.42 Cr
Rate of Return 32%
Break Even Point 50%
CONTENTS
INTRODUCTION
MICRO CRYSTALLINE CELLULOSE
MICRO CRYSTALLINE CELLULOSE
APPLICATIONS
SPECIFICATION
USES AND APPLICATION
CELLULOSE IS USED IN THE FOLLOWING PRODUCTS:
FIBERS:-
FILMS:-
CELLOPHANE:-
SAUSAGE CASINGS:-
ARTIFICIAL KIDNEYS:-
REVERSE OSMOSIS:-
GUMS & THICKNESS
FOODS & PHARMACEUTICALS FOODS
PHARMACEUTICALS
COSMETICS
MARKET SURVEY
EXPORT DATA OF MICRO CRYSTALLINE CELLULOSE
IMPORT DATA OF MICRO CRYSTALLINE CELLULOSE
PRESENT MANUFACTURERS/SUPPLIERS OF MICRO CRYSTALLINE CELLULOSE
B I S SPECIFICATION
1. SCOPE
2. REQUIREMENTS
3. PACKING AND MARKING
4. SAMPLING
5. TEST METHODS
METHODS OF TEST 28
SAMPLING OF CELLULOSE POWDER
CELLULOSE DERIVATES
1. CELLULOSE ACETATE:
2. SIMPLE TRIESTERS:
3. CELLULOSE ESTERS OF AROMATIC ACIDS:
4. BENZOATE ESTERS:
5. CELLULOSE ESTERS OF UNSATURATED CARBOXYLIC ACIDS:
6. MIXED ESTERS:
SPECIFICATION OF MICROCRYSTALLINE CELLULOSE
COMPARISON CHART OF SPECIFICATOINS
MICROCRYSTALLINE CELLULOSE, IP (SPRAY DRIED)
MICROCRYSTALLINE CELLULOSE, IP (BULK DRIED)
SPECIFICATION OF FOOD GRADE (MCC)
RAW MATERIALS
PROPERTIES
PHYSICAL PROPERTIES:
HEAT EFFECTS :
SOLUBILITY :
CHEMICAL PROPERTIES :
PROPERTIES IN ALKALINE SOLUTION:
EFFECT OF MINERAL ACIDS :
EFFECT OF OXIDIZING AGENTS :
ALCOHOLIC PROPERTIES :
ETHER FORMATION :
MANUFACTURING PROCESS OF MICROCRYSTALLINE CELLULOSE POWDER
PROCESS FLOW DIAGRAM
PROCESS DETAILS
1. WOOD PREPARATION :
2. PULPING:
MECHANICAL PULPING :
CHEMICAL PULPING :
SULFITE PROCESSES :
ALKALINE PROCESSES :
PURIFICATION ;
OXIDATIVE BLEACHING : CHLORINE.
OTHER AGENTS :
REDUCTIVE BLEACHING:
OTHER REACTIONS :
THE USUAL METHODS INCLUDE EITHER OR BOTH OF THESE STEPS:
PRODUCTION OF MICROCRYSTALLINE CELLULOSE USING REACTIVE
EXTRUSION PROCESS
TEST METHODS
TABLE 1: TABLET PROPERTIES
MANUFACTURING PROCESS OF MICRO CRYSTALLINE CELLULOSE FROM CORN HUSK
MATERIALS AND METHOD
MATERIALS
METHOD
PREPARATION OF MAIZE HUSK POWDER:
EXTRACTION OF CELLULOSE FROM CORN HUSK:
MICRO CRYSTALLINE CELLULOSE FROM COTTON RAGS
REAGENTS AND CHEMICALS
MCC PREPARATION
PURITY AND IDENTIFICATION TEST
SUPPLIERS OF RAW MATERIALS
SUPPLIERS OF PLANT AND MACHINERY
APPENDIX – A:
01. PLANT ECONOMICS
02. LAND & BUILDING
03. PLANT AND MACHINERY
04. OTHER FIXED ASSESTS
05. FIXED CAPITAL
06. RAW MATERIAL
07. SALARY AND WAGES
08. UTILITIES AND OVERHEADS
09. TOTAL WORKING CAPITAL
10. TOTAL CAPITAL INVESTMENT
11. COST OF PRODUCTION
12. TURN OVER/ANNUM
13. BREAK EVEN POINT
14. RESOURCES FOR FINANCE
15. INSTALMENT PAYABLE IN 5 YEARS
16. DEPRECIATION CHART FOR 5 YEARS
17. PROFIT ANALYSIS FOR 5 YEARS
18. PROJECTED BALANCE SHEET FOR (5 YEARS)
