EPHEDRINE HYDROCHLORIDE
[EIRI/EDPR/1365] (J.C.135)
INTRODUCTION
The Chinese herb mixture "Ma Huang" has been used empirically by native physicians for more than 5000 years. "Ma Huang", which contains ophedrine, has also been widely used in U.S.S.R. in the treatment of various disorders. While the driatic activity of the alkaloid ephedrine was first demonstrated in 1887 by Miura, the use of ephedrine as a my driatic enjoyed only a passing vogue. International interest in the drug was stimulated in 1924 by the classical investigations of Chen and Schmidt, who reported its cardiovascular effects, its similarity to epinephrine and its absorption from the intestinal tract.
Ephedrine (1-phenyl-2-methylaminopropanol) (C6 H5 CH COH) CH (NH. CH3). CH3 is optically active (Levorotatory) form, which is white to colourless granules, pieces or crystals, hygroscopic in nature and gradually decomposes on exposure to light. It is soluble in water, alcohol, ether, chloroform and oils. Its major use in medicine is as bronchodilator.
COST ESTIMATION
Plant Capacity 300 Kg/Day
Land & Building (1500 sq.mt.) Rs. 1.19 Cr
Plant & Machinery Rs. 1.08 Cr
Working Capital for 2 Months Rs. 94.92 Lac
Total Capital Investment Rs. 3.54 Cr
Rate of Return 34%
Break Even Point 51%
CONTENTS
INTRODUCTION
COMMERCIAL IMPORTANCE
PROPERTIES OF EPHEDRINE
PROPERTIES OF EPHEDRINE HYDROCHLORIDE
USES AND APPLICATIONS
MANUFACTURERS/SUPPLIERS OF EPHEDRINE HYDROCHLORIDE
PROCESS OF MANUFACTURE
PROCESS FLOW SHEET FOR THE MANUFACTURE OF EPHEDRINE HYDROCHLORIDE (KETOL)
OTHER RELATED INFORMATIONS
SUPPLIERS OF PLANT & MACHINERY
MANUFACTURERS/SUPPLIERS OF RAW MATERIALS
PLANT LAYOUT
APPENDIX – A:
01. PLANT ECONOMICS
02. LAND & BUILDING
03. PLANT AND MACHINERY
04. OTHER FIXED ASSESTS
05. FIXED CAPITAL
06. RAW MATERIAL
07. SALARY AND WAGES
08. UTILITIES AND OVERHEADS
09. TOTAL WORKING CAPITAL
10. TOTAL CAPITAL INVESTMENT
11. COST OF PRODUCTION
12. TURN OVER/ANNUM
13. BREAK EVEN POINT
14. RESOURCES FOR FINANCE
15. INSTALMENT PAYABLE IN 5 YEARS
16. DEPRECIATION CHART FOR 5 YEARS
17. PROFIT ANALYSIS FOR 5 YEARS
18. PROJECTED BALANCE SHEET FOR (5 YEARS)
