VISCOELASTIC SOLUTION
[EIRI/EDPR/4632]
Viscoelastics are also known as ophthalmic viscosurgical devices. They are solutions with dual properties. They have viscous properties of a fluid and elastic properties of a gel or a solid. They have also been described to have viscous, elastic, and pseudoplastic properties.
Viscoelastics are commonly used in cataract surgery to assist in capsulotomy and nucleus manipulation, corneal surgeries, glaucoma surgeries, open globe repairs, retinal surgery, pediatric and strabismus surgeries. Viscoelastics can be classified based on the source and rheological properties. The various complications associated with viscoelastics are secondary glaucoma, capsular block syndrome, capsular bag distension syndrome, pseudo anterior uveitis, IOL crystallization, and calcific band keratopathy.
COST ESTIMATION
Plant Capacity 3845 Kg/Day
Land & Building (4000 sq.mt.) Rs. 3.74 Cr
Plant & Machinery Rs. 1.10 Cr
Working Capital for 1 Month Rs. 1.58 Cr
Total Capital Investment Rs. 6.53 Cr
Rate of Return 67%
Break Even Point 35%
CONTENTS
INTRODUCTION
PROPERTIES & CHARACTERISTICS
PHYSICAL AND RHEOLOGICAL PROPERTIES OF VISCOELASTICS
VISCOSITY
PSEUDO-PLASTICITY
VISCOELASTICITY
RIGIDITY
SURFACE TENSION
VISCOADAPTABILITY
COHESIVENESS
DISPERSIVENESS
COATABILITY
CLASSIFICATION OF VISCOELASTICS
VISCOELASTICS ARE CLASSIFIED BASED ON THE
CLASSIFICATION BASED ON RHEOLOGICAL PROPERTIES
ARSHINOFF'S CLASSIFICATION
USES AND APPLICATION
CATARACT SURGERY
GLAUCOMA SURGERIES
CORNEAL SURGERIES
VISCOANAESTHESIA
VISCOMYDRIASIS
INTRAOPERATIVE FLOPPY IRIS SYNDROME (IFIS)
RETINAL SURGERY
ORBIT AND OCULOPLASTY SURGERY
PEDIATRIC OPHTHALMOLOGY AND STRABISMUS SURGERY
MANUFACTURING PROCESS OF VISCOELASTIC POLYMER (HPMC) HYDROXY PROPYL METHYL CELLULOSE
REACTION:
SIDE REACTION:
PROCESS FLOW DIAGRAM OF HPMC
PREPARATION OF VISCOELASTICS
SODIUM HYALURONATE
CHONDROITIN SULPHATE
VARIOUS PREPARATIONS OF CHONDROITIN SULPHATE
ISOLATED CHONDROITIN SULPHATE (20%)
CHONDROITIN SULPHATE AND SODIUM HYALURONATE
HYDROXYPROPYL METHYLCELLULOSE (HPMC)
SYNTHETIC VISCOELASTICS MATERIAL FOR OPHTHALMIC APPLICATION
EXAMPLE 1
VISCOELASTIC SOLUTIONS
SPECIALITIES
HYDROXY PROPYLMETHYL CELLULOSE OPHTHALMIC SOLUTION USP
AVAILABLE IN
CHARACTERISTICS
MARKET OVERVIEW OF VISCOLASTICS
GLOBAL OVERVIEW OF VISCOELASTIC
PRINCIPLES OF PLANT LAYOUT
STORAGE LAYOUT:
EQUIPMENT LAYOUT:
SAFETY:
PLANT EXPANSION:
FLOOR SPACE:
UTILITIES SERVICING:
BUILDING:
MATERIAL-HANDLING EQUIPMENT:
RAILROADS AND ROADS:
MAJOR PROVISIONS IN ROAD PLANNING FOR MULTIPURPOSE SERVICE ARE:
PLANT LOCATION FACTORS
PRIMARY FACTORS
1. RAW-MATERIAL SUPPLY:
2. MARKETS:
3. POWER AND FUEL SUPPLY:
4. WATER SUPPLY:
5. CLIMATE:
SPECIFIC FACTORS
6. TRANSPORTATION:
A. AVAILABILITY OF VARIOUS SERVICES AND PROJECTED RATES
7. WASTE DISPOSAL:
8. LABOR:
9. REGULATORY LAWS:
10. TAXES:
11. SITE CHARACTERISTICS:
12. COMMUNITY FACTORS:
13. VULNERABILITY TO WARTIME ATTACK:
14. FLOOD AND FIRE CONTROL:
EXPLANATION OF TERMS USED IN THE PROJECT REPORT
1. DEPRECIATION:
2. FIXED ASSETS:
3. WORKING CAPITAL:
4. BREAK-EVEN POINT:
5. OTHER FIXED EXPENSES:
6. MARGIN MONEY:
7. TOTAL LOAD:
8. LAND AREA/MAN POWER RATIO:
PROJECT IMPLEMENTATION SCHEDULES
INTRODUCTION
PROJECT HANDLING
PROJECT SCHEDULING
PROJECT CONSTRUCTION SCHEDULE
TIME SCHEDULE
ADDRESSES OF RAW MATERIAL SUPPLIERS
ADDRESSES OF PLANT & MACHINERY SUPPLIERS
APPENDIX – A:
01. PLANT ECONOMICS
02. LAND & BUILDING
03. PLANT AND MACHINERY
04. OTHER FIXED ASSESTS
05. FIXED CAPITAL
06. RAW MATERIAL
07. SALARY AND WAGES
08. UTILITIES AND OVERHEADS
09. TOTAL WORKING CAPITAL
10. TOTAL CAPITAL INVESTMENT
11. COST OF PRODUCTION
12. TURN OVER/ANNUM
13. BREAK EVEN POINT
14. RESOURCES FOR FINANCE
15. INSTALMENT PAYABLE IN 5 YEARS
16. DEPRECIATION CHART FOR 5 YEARS
17. PROFIT ANALYSIS FOR 5 YEARS
18. PROJECTED BALANCE SHEET FOR (5 YEARS)
